2022 Research Highlights (see details below)

• Breakthrough gene therapy results showing rescue of FOXG1 brain structure, behavior, memory and cognition symptoms in animal models

• Positive results on initial compound drug screens to identify molecules to increase FOXG1 levels; now moving forward to larger screens

• Never-before understanding of FOXG1 biology uncovered from six FOXG1 patient human cell lines and mouse models 

• Successful testing of guide RNAs to increase FOXG1 expression with a CRISPRa Cas-9 system

• Discovered ASO sequences (antisense gene therapy) to modulate FOXG1 expression; testing initiated with Creyon Bio  

• FOXG1 data package presented to several biotech companies with high interest